<p class="ql-block">2025年来到了，四川大学华西医院皮肤科冉玉平教授团队以真菌和皮肤为主题来做了蛇年台历，供大家分享</p><p class="ql-block">The 2025 has arrived, Prof. Ran Yuping’s team from the Department of Dermatology at West China Hospital of Sichuan University has created a Snake Year calendar with fungi & skin as the theme for everyone sharing</p> <p class="ql-block">所显示蛇🐍的图案不是一般的蛇，这是冉教授团队原创的"真菌"蛇！由6种念珠菌在科玛嘉显色培养基上30度72小时长出来的蛇，还背了个“金元宝”，寓意蛇年吉祥如意</p><p class="ql-block">The snake displayed is not an ordinary; it is an original creation by our team called the "Fungal Snake"! It was grown from six species of <i>Candida spp</i>. on a CHROMagar medium at 30℃ for 72 hours. The snake even carries a "golden ingot" on its back, symbolizing good fortune and prosperity in the Year of the Snake</p> <p class="ql-block">绿色代表白念珠菌，粉色代表克柔念珠菌，淡紫色代表光滑念珠菌，白色代表耳念珠菌，黄色代表近平滑念珠菌，铁蓝色代表热带念珠菌</p><p class="ql-block">Green: <i>Candida albians</i>; Pink: <i>Candida krusei</i>; Lavender: <i>Candida glabrata</i>; White: <i>Candida auris</i>; Yellow: <i>Candida parapsilosis</i>; Blue: <i>Candida tropicalis</i></p> <p class="ql-block">一月：蛇年新气象</p><p class="ql-block">• 此图像为新暗色柱状孢的显微镜下观察普通光源和荧光染色所见，形如“贪吃蛇”，此菌常引起植物病变，可因外伤植入皮肤而感染致病 </p><p class="ql-block">• 1月是农历腊月，蛇年代表着智慧和变革，适合年末总结和反思，规划新一年目标.气温较低，需注意保暖，预防感冒等呼吸道疾病</p><p class="ql-block">• 保持皮肤清洁, 使用保湿护肤品防止皮肤干裂.注意脚部卫生，勤换鞋袜，预防脚癣等真菌感染，适当用润唇膏防止嘴唇干裂 </p><p class="ql-block">• 川渝皮肤年会在重庆召开：老四川的团聚会，辞旧迎新团年会，家门口的全国会</p> <p class="ql-block">January: A Fresh Start in the Year of the Snake</p><p class="ql-block">This image shows the observation of the common light source and fluorescence staining of <i>Neoscytalidium dimidiatum</i> under the microscope, which resembles the "Snake Feast." This fungus often causes plant diseases and can infect and cause illness in the skin through trauma</p><p class="ql-block">January is the twelfth lunar month, and the Year of the Snake represents wisdom and transformation, making it a perfect time for year-end summaries and reflections, as well as planning for new year goals. The temperature is low, so it's important to keep warm and prevent respiratory diseases such as colds</p><p class="ql-block">Keep the skin clean and use moisturizing skincare products to prevent chapped skin. Pay attention to foot hygiene, change shoes and socks frequently, and prevent fungal infections like athlete's foot. Use lip balm appropriately to prevent chapped lips</p><p class="ql-block">The Sichuan-Chongqing Skin Annual Conference will be held in Chongqing. It is a reunion for the dermatologists of old Sichuan, a new year's gathering to bid farewell to the old and welcome the new, a national conference right at home</p> <p class="ql-block">二月：蛇舞新春</p><p class="ql-block">• 此为透射电镜观察胶原纤维的横断面图像，是皮肤的重要组成部分，主要存在于真皮层。为皮肤提供结构支撑和弹性，使皮肤保持紧致和光滑。胶原纤维合成减少将致皮肤松弛和皱纹等老化现象。胶原纤维还参与伤口愈合，促进新生组织的形成</p><p class="ql-block">• 考考你的眼力：在胶原纤维中隐藏着一条蛇</p><p class="ql-block">• 立春后，万物复苏，蛇年象征着生命力和活力，适合出行游玩，开阔视野。但早晚温差大，仍需注意防寒保暖</p><p class="ql-block">• 选择透气性好的衣物，避免皮肤长时间处于潮湿环境中。在公共场所如游泳池、健身房等，尽量避免穿他人拖鞋或赤脚行走。外出度假要涂抹防嗮霜，保护皮肤免受紫外线伤害 </p> <p class="ql-block">February: Snake Dance in the New Spring</p><p class="ql-block">• This is a cross-sectional image of collagen fibers under a transmission electron microscope. They are an essential component of the skin, primarily located in the dermis. Collagen fibers provide structural support and elasticity, keeping the skin firm and smooth. A decrease in collagen fiber synthesis can lead to skin laxity and wrinkles, among other signs of aging. Collagen fibers also participate in wound healing, promoting the formation of new tissue</p><p class="ql-block">• Test your observation skills: A snake is hidden among the collagen fibers</p><p class="ql-block">• After the Start of Spring, everything comes back to life, and the Year of the Snake symbolizes vitality and energy, making it a great time for traveling and broadening horizons. However, the temperature difference between day and night is still large, so it's important to keep warm</p><p class="ql-block">• Choose breathable clothing to avoid damp skin for long periods. In public places like swimming pools and gyms, try to avoid wearing others' slippers or walking barefoot. When going on vacation, apply sunscreen to protect the skin from UV damage</p> <p class="ql-block">三月：蛇年春意浓</p><p class="ql-block">• 此为白念珠菌酵母细胞出芽和形成的假菌丝，犹如初春的新绿。白念珠菌是皮肤和黏膜的常驻真菌，在屏障受损和免疫力低下人群容易机会感染</p><p class="ql-block">• 保持个人卫生，勤洗手，避免与他人共用毛巾、浴巾等个人物品.定期清洁居住环境，减少尘螨等过敏原.外出时戴口罩，防止花粉过敏 </p><p class="ql-block">• 进入春天后，蛇年寓意灵动和智慧，有利于个人事业发展，适合获取新的合作机会</p><p class="ql-block">• 3月学术活跃，7-9日是华西皮肤论坛，需合理安排，协调行程，注意安全</p> <p class="ql-block">March: The Year of the Snake Brings Spring</p><p class="ql-block">• This image shows yeast cells of <i>Candida albicans</i> budding and forming pseudohyphae, resembling the fresh green of early spring. <i>C. albicans</i> is a resident fungus on the skin mucous membranes, and it can cause opportunistic infections in people with compromised barriers and weakened immunity.</p><p class="ql-block">• Maintain personal hygiene, wash hands frequently, and avoid sharing personal items like towels and bath towels with others. Regularly clean your living environment to reduce allergens such as dust mites. Wear a mask when going out to prevent pollen allergies.</p><p class="ql-block">• As spring arrives, the Year of the Snake symbolizes agility and wisdom, which is conducive to personal career development and obtaining new cooperation opportunities.</p><p class="ql-block">• Academic activities are bustling in March. West China Hospital Dermatology Forum will be held in Chengdu from March 7- 9. AAD Annual Meeting will be held on Florida. It's important to arrange and coordinate your schedule reasonably and pay attention to safety.</p> <p class="ql-block">四月：蛇年春光好</p><p class="ql-block">• 此为犬小孢子菌小培养所见大分生孢子和小分生孢子，荧光染色能清晰看到分隔和细胞壁，荧光越亮表示几丁质合成代谢越活跃。犬小孢子菌可引起动物掉毛，感染儿童引起头癣和体癣等，养宠物者要小心</p><p class="ql-block">• 春意正浓，蛇年象征着生命的延续和繁衍，适合踏青赏花，享受大自然的美好。但紫外线逐渐增强，外出时使用防晒霜、遮阳帽等，避免暴晒。保持充足睡眠，增强免疫力，降低感染风险</p><p class="ql-block">• 真菌继续教育培训班将在孔子故乡济宁举办，中西医结合皮肤会将在大都会上海举行</p> <p class="ql-block">April: The Year of the Snake Brings Beautiful Spring</p><p class="ql-block">• This image shows Macro- and micro- conidia from a slide culture of <i>Microsporum canis</i>, with fluorescence staining clearly revealing the septa and cell walls. The brighter the fluorescence, the more active the chitin synthesis metabolism. <i>M. canis</i> can cause animals to shed hair and can infect children, leading to tinea capitis or tinea corporis. Pet owners should be cautious</p><p class="ql-block">• Spring is in full swing, and the Year of the Snake symbolizes the continuation and proliferation of life, making it a perfect time for enjoying nature by visiting parks and appreciating flowers. However, as ultraviolet (UV) rays gradually intensify, it's important to protect your skin from the sun，use sunscreen and wear sun hats to avoid prolonged exposure to sunlight. Maintain adequate sleep to boost your immune system and reduce the risk of infections</p><p class="ql-block">• A CBS-fungal continuing education training program will be held in Jining, the hometown of Confucius, and the Sino-Western Medicine Combined Dermatology Conference will take place in the metropolis of Shanghai</p> <p class="ql-block">五月：蛇年生机勃发</p><p class="ql-block">• 此为新生隐球菌侵犯皮下组织的透射电镜相片：真菌细胞壁外层包裹着厚厚的荚膜，周边与皮下组织有宽宽的间隙。常寄生在鸽子消化道，耐高温，吸入鸽粪中隐球菌孢子可引起肺部感染，经血脑屏障致新生隐球菌脑炎</p><p class="ql-block">• 5月是春夏交替之际，蛇年代表着智慧和谋略，适合户外运动和旅游。但蚊虫开始活跃，需注意防虫咬皮炎</p><p class="ql-block">• 穿着宽松、透气衣物，户外活动时避免被蚊虫叮咬。定期更换床单、毛巾等贴身用品，以减少细菌和真菌滋生</p><p class="ql-block">• 5月有人口文化真菌病年会（上海），还有国际人类和动物真菌学年会（巴西）</p> <p class="ql-block">May: The Year of the Snake Brings Vitality</p><p class="ql-block">• This is a transmission electron microscope image of <i>Cryptococcus neoformans</i> invading subcutaneous tissue: The fungal cell wall is enveloped by a thick capsule, with a wide gap surrounding it and the subcutaneous tissue. It commonly parasitizes the digestive tract of pigeons, is heat-resistant, and inhaling cryptococcal spores from pigeon droppings can cause lung infections, which can lead to cryptococcal meningitis by crossing the blood-brain barrier.</p><p class="ql-block">• May marks the transition from spring to summer, and the Year of the Snake symbolizes wisdom and strategy, making it a great time for outdoor sports and travel. However, insects begin to become active, so it's important to prevent insect bite dermatitis.</p><p class="ql-block">• Wear loose, breathable clothing to avoid damp skin for long periods. When engaging in outdoor activities, use insect repellent to avoid insect bites. Regularly change bed sheets, towels, and other personal items to reduce the growth of bacteria and fungi.</p><p class="ql-block">• In May, there is the Population Culture Fungal Disease Annual Conference in Shanghai, as well as the Conference of International Socity on Human and Animal Mycology in Brazil.</p> <p class="ql-block">六月：蛇年盛夏至</p><p class="ql-block">• 为尘螨的扫描电镜图像，特别放大观察其口器，叮咬皮肤，引起炎症反应，瘙痒剧烈。应保持室内干燥、不用地毯，不养宠物，定期清洗沙发和床上用品等</p><p class="ql-block">• 6月是夏季的开始，蛇年象征着顽强的生命力。气温持续升高，天气炎热，户外需注意防暑降温</p><p class="ql-block">• 勤洗澡，保持皮肤清洁干燥，避免汗液滋生细菌.选择透气性好的鞋袜，预防脚气等真菌感染.外出时携带遮阳伞和太阳镜，全方位防晒</p><p class="ql-block">• 国际光动力大会（上海）、全国皮肤科年会（长沙）和国际皮肤科大会（罗马）推动皮肤科学术交流</p> <p class="ql-block">June: The Year of the Snake Brings the Height of Summer</p><p class="ql-block">• This is a scanning electron microscope image of a house dust mite, with a close-up view of its mouthparts. House dust mites can bite the skin, causing inflammatory reactions and severe itching. To prevent this, maintain a dry indoor environment, avoid using carpets, refrain from keeping pets, and regularly clean sofas and bedding</p><p class="ql-block">• June marks the beginning of summer, and the Year of the Snake symbolizes tenacious vitality. As temperatures continue to rise and the weather becomes hot, it's important to take precautions to prevent heatstroke when outdoors</p><p class="ql-block">• Shower frequently to keep the skin clean and dry, preventing bacteria from thriving in sweat. Choose breathable shoes and socks to prevent fungal infections like athlete's foot. When going out, carry a sun umbrella and sunglasses for comprehensive sun protection</p><p class="ql-block">• The International Photodynamic Therapy Conference in Shanghai, the Chinese Society of Dermatology Annual Meeting in Changsha, and the International Dermatology Congress in Rome promote academic exchanges in the field of dermatology</p> <p class="ql-block">七月：蛇年炎炎夏日</p><p class="ql-block">• 脓肿分枝杆菌是一种快速生长型非结核分枝杆菌，广泛存在于土壤和水等环境中，常因外伤和不规范美容操作导致皮肤和软组织感染，对多种抗生素具有天然耐药性，治疗难度较大</p><p class="ql-block">• 7月是盛夏时节，蛇年代表着神秘和智慧，适合创新和探索.但气温达到一年中最高点，应避免长时间在高温环境下活动，及时补充水分和电解质.保持通风和干燥，减少真菌滋生.外出时每两小时补涂一次防晒霜，确保防晒效果 </p><p class="ql-block">• 成都高新医学会皮肤病与美容学分会年会召开，是汇集海内外学者智慧，高水平创新学术交流的品牌会议</p> <p class="ql-block">July: The Year of the Snake Brings the Heat of Summer</p><p class="ql-block">• <i>Mycobacterium abscessus</i> is a rapidly growing non-tuberculous mycobacterium found in soil and water. It often causes skin and soft tissue infections due to trauma and improper cosmetic procedures, showing resistance to many antibiotics.</p><p class="ql-block">• In July, as summer peaks, the Year of the Snake symbolizes mystery and wisdom, perfect for innovation and exploration. Avoid prolonged exposure to high temperatures, stay hydrated, and keep areas well-ventilated to prevent fungal growth. Reapply sunscreen every two hours when outdoors.</p><p class="ql-block">• The Chengdu High-Tech Medical Association Dermatology and Cosmetic Society Annual Conference is a high-level academic event, gathering experts from around the world to share insights and innovations in dermatology</p> <p class="ql-block">八月：蛇年夏末秋初</p><p class="ql-block">• 显示单梗着色霉（<i>Fonsecaea monophora</i>）的菌落和用皮肤镜放大后放射性分布的菌丝体，这种暗色真菌广泛存在于潮湿腐烂树木、植物和泥土中, 经皮肤和黏膜损伤导致皮肤疣状增生或溃疡，引起着色芽生菌病，严重影响生活质量</p><p class="ql-block">• 8月是夏末秋初，蛇年象征着冷静和深思熟虑，适对工作与生活全面总结.但仍然炎热，需注意防暑降温</p><p class="ql-block">• 保持皮肤清洁干燥，避免穿潮湿衣物，避免食用过期或不卫生食物，不采食野生蘑菇以免中毒.外出时防晒穿长袖衣物和戴宽边帽</p><p class="ql-block">• 中国菌物学年会将在南昌举行，这是所有菌物人的盛会</p> <p class="ql-block">August: The Transition from Summer to Autumn in the Year of the Snake</p><p class="ql-block">• The image shows the colonies of <i>Fonsecaea monophora</i> and its radiating hyphae magnified by a dermatoscope. This dark-colored fungus is widely found in damp, decaying trees, plants, and soil. It causes skin verrucous hyperplasia or ulcers and leads to chromoblastomycosis through skin and mucous membrane injuries, severely affecting the quality of life.</p><p class="ql-block">• August marks the transition from summer to autumn, and the Year of the Snake symbolizes calmness and thoughtfulness, making it an ideal time for a comprehensive review of work and life. However, the weather is still hot, so it's important to stay cool.</p><p class="ql-block">• Keep the skin clean and dry, avoid wearing damp clothes, refrain from consuming expired or unhygienic food, and do not forage wild mushrooms to prevent poisoning. When going out, apply sunscreen and wear long-sleeved clothing and wide-brimmed hats.</p><p class="ql-block">• The Chinese Mycology Annual Conference will be held in Nanchang, a grand event for all mycologists.</p> <p class="ql-block">九月：蛇年秋高气爽</p><p class="ql-block">• 涂片所见新生隐球菌在墨汁染色、革兰染色和荧光染色后的镜下形态，荚膜是该菌的特点，免疫受损者易感然新生隐球菌，是非常危险的担子菌</p><p class="ql-block">• 9月是秋季的开始，蛇年代表着智慧和敏锐，适合制定新计划.但早晚温差大，注意衣着调整.定期清洁居住环境，减少尘螨等过敏原</p><p class="ql-block">• 全球华人皮肤病高峰论坛将在香港举办，欧洲皮肤科年会将在巴黎举行</p> <p class="ql-block">September: The Year of the Snake Brings a Refreshing Autumn</p><p class="ql-block">• The microscopic appearance of <i>Cryptococcus neoformans</i> after smearing and staining with India ink, Gram stain, and fluorescence reveals the characteristic capsule of this fungus. It is particularly dangerous for immunocompromised individuals, making it a very hazardous basidiomycete.</p><p class="ql-block">• September marks the beginning of autumn, and the Year of the Snake symbolizes wisdom and keenness, making it an ideal time to set new plans. However, the temperature difference between day and night is significant, so adjust clothing accordingly. Regularly clean your living environment to reduce allergens like dust mites.</p><p class="ql-block">• The Global Chinese Dermatology Summit will be held in Hong Kong, and the European Academy of Dermatology and Venereology Annual Meeting will take place in Paris.</p> <p class="ql-block">十月：蛇年丰收季</p><p class="ql-block">• 须癣毛癣菌为亲动物皮肤癣菌，荧光染色后镜下呈亮蓝色螺旋样菌丝、密集小分生孢子和大分生孢子，此菌容易引起头癣和体癣</p><p class="ql-block">• 10月是秋季的中期，蛇年象征着收获和成功，适合工作与生活总结，也是丰收季节，需做好收获和储存</p><p class="ql-block">• 保持个人卫生，勤洗手，避免与他人共用毛巾、浴巾等个人物品.注意饮食均衡，增强免疫力.外出时涂抹防嗮霜，保护皮肤免受紫外线伤害</p><p class="ql-block">• 全国毛发大会在西安召开，分享斑秃，雄秃和头癣等毛发疾病基础和诊治经验</p> <p class="ql-block">October: The Harvest Season of the Year of the Snake</p><p class="ql-block">• <i>Trichophyton mentagrophytes</i> is a zoophilic dermatophyte. After fluorescence staining, it appears as bright blue spiral hyphae, dense small conidia, and large conidia under the microscope. This fungus easily causes tinea capitis and tinea corporis</p><p class="ql-block">• October is the middle of autumn, and the Year of the Snake symbolizes harvest and success, making it an ideal time for summarizing work and life. It is also the harvest season, so it's important to prepare for gathering and storage</p><p class="ql-block">• Maintain personal hygiene, wash hands frequently, and avoid sharing personal items like towels and bath towels with others. Pay attention to a balanced diet to enhance immunity. Apply sunscreen when going out to protect the skin from UV damage</p><p class="ql-block">• The Chinese Hair Congress will be held in Xi'an, where experiences in the basic knowledge and treatment of hair diseases such as alopecia areata, androgenetic alopecia, and tinea capitis will be shared</p> <p class="ql-block">十一月：蛇年秋意渐浓</p><p class="ql-block">• 显示单梗着色霉侵犯皮下组织后，皮肤镜下所见“黑红点征”在透射电镜下菌体有皮下向体外排出的现象，为我们团队首先观察到：犹如海浪把砂石拍到沙滩上</p><p class="ql-block">• 11月是秋季后期，蛇年代表着冷静和深思熟虑，适合进行反思和规划.气温逐渐降低，需防寒保暖，用保湿护肤品防止皮肤干裂，注意脚部卫生，适当增加护肤品中的油脂含量，以锁住皮肤水分</p><p class="ql-block">• 全国皮肤科医师年会将在重庆召开，皮肤科医师将感受回家的温暖</p> <p class="ql-block">November: The Year of the Snake Brings a Deepening Autumn</p><p class="ql-block">• The image shows the "black-red dot sign" observed under a dermatoscope after <i>Fonsecaea monophora</i> invades subcutaneous tissue, with the fungal bodies being expelled from the subcutaneous tissue to the outside under a transmission electron microscope. This phenomenon was first observed by our team, resembling waves washing sand onto the beach.</p><p class="ql-block">• November marks the later stage of autumn, and the Year of the Snake symbolizes calmness and thoughtfulness, making it an ideal time for reflection and planning. As temperatures gradually decrease, it's important to keep warm, use moisturizing skincare products to prevent chapped skin, pay attention to foot hygiene, and appropriately increase the oil content in skincare products to lock in skin moisture.</p><p class="ql-block">• The Chinese Dermatology Associations Annual Conference will be held in Chongqing, where dermatologists will experience the warmth of returning home.</p> <p class="ql-block">十二月：蛇年静心反思</p><p class="ql-block">• 显示须癣毛癣菌侵犯毛球部的扫描电镜图像，引起脱发断发和严重的头皮炎症，儿童是最容易感染人群，避免与宠物亲密接触是最重要的预防措施</p><p class="ql-block">• 12月是农历腊月，蛇年象征着智慧和变革，适合放松与减压，展现新一年美好愿景.冬季气温寒冷注意防寒保暖</p><p class="ql-block">• 冬季蛇进入冬眠状态，养精储锐，来年再战. 保持充足睡眠，增强免疫力降低感染风险.使用滋润度高的护肤品，防止皮肤干燥</p> <p class="ql-block">December: The Year of the Snake Brings Reflection and Calm</p><p class="ql-block">• The image shows a scanning electron microscope view of <i>Trichophyton mentagrophytes</i> invading the hair bulb, causing hair loss, broken hair, and severe scalp inflammation. Children are the most susceptible to infection, and avoiding close contact with pets is the most important preventive measure.</p><p class="ql-block">• December is the twelfth lunar month, and the Year of the Snake symbolizes wisdom and transformation, making it an ideal time for relaxation and stress reduction, as well as envisioning a bright new year. With the cold winter temperatures, it's important to stay warm.</p><p class="ql-block">• Snakes enter hibernation in winter to conserve energy and prepare for the next year. Maintain adequate sleep to boost immunity and reduce the risk of infection. Use highly moisturizing skincare products to prevent dry skin.</p> <p class="ql-block">2026年1月</p><p class="ql-block"> 显示新生隐球菌的扫描电镜观察，表面饱满光滑或皱折凹陷，反映不同活性状态</p><p class="ql-block"> 2026年1月仍然是蛇年，川渝皮肤年会将月1月23-25在成都召开，做好准备分享成果。注意保暖</p><p class="ql-block"> 等待2月进入马年，万马奔腾，气象万新</p> <p class="ql-block">January 2026</p><p class="ql-block">• The scanning electron microscope observation of <i>Cryptococcus neoformans</i> shows a surface that is either plump and smooth or wrinkled and indented, reflecting different states of activity.</p><p class="ql-block">• January 2026 is still the Year of the Snake. The Sichuan-Chongqing Dermatology Annual Conference will be held in Chengdu from January 23 to 25. Be prepared to share your achievements and keep warm.</p><p class="ql-block">• Look forward to entering the Year of the Horse in February, with a vibrant and refreshing atmosphere.</p> <p class="ql-block">冉玉平教授团队出版了《挑战疑难病-SCI论文背后的故事》。感谢廖万清院士和陈洪铎院士题词“授人以渔”，“点石成金”</p> <p class="ql-block">《挑战疑难病-SCI论文背后的故事》第一辑（故事1-30），扫描二维码可订购。</p><p class="ql-block">Professor Ran Yuping's team has published the Part 1 of " Challenging Difficult Diseases -Stories Behind SCI Papers" (Stories 1-30)</p> <p class="ql-block">《挑战疑难病-SCI论文背后的故事》第二辑（故事31-60），扫描二维码可购书。</p><p class="ql-block">The Part 2 of "Challenging Difficult Diseases - Stories Behind SCI Papers" (Stories 31-60) .</p>