<p class="ql-block">2022年也是及其不平凡的一年，疫情肆虐，打乱了正常生活节律。这也是我退休返聘生活的开始，度过我六十六岁喜寿之年。但这一年，我仍然在自己的工作岗位上，努力拼搏，发挥余热，取得满意的成绩。现将一年工作情况做一简要小结：</p><p class="ql-block">1.发表SCI论文17篇，其中10分以上3篇CRITICAL CARE（IF19.33），5分以上9篇，总影响因子122.818，平均每篇论文影响因子＞7分</p><p class="ql-block">2.湖北省技术创新专项重大项目答辩，“围术期呼吸系统管理策略创新优化”和国基金面上项目“”迷走神经刺激脂氧素调控急性肺损伤炎症消退机制”以优秀成绩结题</p><p class="ql-block">3. 机械通气诱发肺损伤新机制及围术期防御体系的建立与应用 作为第二完成人和单位，申报2022年中华医学奖进入二审</p><p class="ql-block">4.两名博士，两名硕士顺利通过论文答辩</p><p class="ql-block">5.作为共同主编人卫《麻醉学新进展2021》出版发行。主编精准麻醉系列产科麻醉学完稿，送出版社编审</p><p class="ql-block">6.牵头申报麻醉国家临床医学中心，参与申报麻醉与复苏教育部重点实验室</p><p class="ql-block">7.湖北省麻醉质控中心位于国内麻醉质控以及湖北省质控前列，分别受到表彰</p><p class="ql-block">8.分娩镇痛推广成绩显著，分别做客人民网，医师报新浪等媒体，推进分娩镇痛推广</p><p class="ql-block">9.健康扶贫走基层 分别走进新疆博乐，喀什，江西赣州萍乡，福建宁德，湖北恩施等地，线上启动西藏，山南麻醉精准帮扶项目</p><p class="ql-block">10.全年乘坐飞机49次，里程53365公里，高铁40次，里程2万多公里，全国各地线上线下交流近100场，是国内最受欢迎的讲者之一</p><p class="ql-block">11.为一位来自新疆博州高风险病人麻醉，获得非常珍贵的锦旗一面。</p><p class="ql-block">12.优秀学生成绩斐然：张定宇成为中共20大代表，王月兰获全国五一奖章，余剑波获第三届健康卫士·医者先锋</p> <p class="ql-block">1.JiaQ,YangY,ChenX,YaoS,HuZ.Emergingrolesofmechanosensitiveionchannelsinacutelunginjury/acuterespiratorydistresssyndrome.RespirRes.2022Dec20;23(1):366.doi:10.1186/s12931-022-02303-3.PMID:36539808;IF:7.1622.</p><p class="ql-block">2.WangF,ZhangY,LiJ,XiaH,ZhangD,YaoS.Thepathogenesisandtherapeuticstrategiesofheatstroke-inducedliverinjury.CritCare.2022Dec17;26(1):391.doi:10.1186/s13054-022-04273-w.PMID:36528615;IF:19.3343.</p><p class="ql-block">3.LiJ,LiM,GeY,ChenJ,MaJ,WangC,SunM,WangL,YaoS,YaoC.β-amyloidproteininducesmitophagy-dependentferroptosisthroughtheCD36/PINK/PARKINpathwayleadingtoblood-brainbarrierdestructioninAlzheimer'sdisease.CellBiosci.2022May26;12(1):69.doi:10.1186/s13578-022-00807-5.PMID:35619150;IF:9.5844.</p><p class="ql-block">4.WangC,YaoC,SunY,ChenJ,GeY,WangY,WangF,WangL,LinY,YaoS.Identificationandverificationofanovelepigenetic-relatedgenesignatureforpredictingtheprognosisofhepatocellularcarcinoma.FrontGenet.2022Nov30;13:897123.doi:10.3389/fgene.2022.897123.PMID:36531219;IF:4.7725.</p><p class="ql-block">5.WangF,ChenM,WangC,XiaH,ZhangD,YaoS.Single-CellSequencingRevealstheRegulatoryRoleofMaresin1onNeutrophilsduringSepticLungInjury.Cells.2022Nov23;11(23):3733.doi:10.3390/cells11233733.PMID:36496993;IF:7.6666.</p><p class="ql-block">6.WangF,ChenM,MaJ,WangC,WangJ,XiaH,ZhangD,YaoS.Integratingbulkandsingle-cellsequencingrevealsthephenotype-associatedcellsubpopulationsinsepsis-inducedacutelunginjury.FrontImmunol.2022Nov2;13:981784.doi:10.3389/fimmu.2022.981784.PMID:36405762;IF:8.7867.</p><p class="ql-block">7.PeiS,WeiW,YangK,YangY,PanY,WeiJ,YaoS,XiaH.RecruitmentManeuvertoReducePostoperativePulmonaryComplicationsafterLaparoscopicAbdominalSurgery:ASystematicReviewandMeta-Analysis.JClinMed.2022Oct1;11(19):5841.doi:10.3390/jcm11195841.PMID:36233708;IF:4.9648.</p><p class="ql-block">8.LiJ,WangX,LiuJ,WangX,LiX,WangY,OuyangW,LiJ,YaoS,ZhuZ,GuoQ,YuY,MengJ,ZuoY.Comparisonofciprofol(HSK3486)versuspropofolfortheinductionofdeepsedationduringgastroscopyandcolonoscopyprocedures:Amulti-centre,non-inferiority,randomized,controlledphase3clinicaltrial.BasicClinPharmacolToxicol.2022Aug;131(2):138-148.doi:10.1111/bcpt.13761.Epub2022Jun10.PMID:35653554;IF:3.6889.</p><p class="ql-block">9.WangF,MaJ,WangJ,ChenM,XiaH,YaoS,ZhangD.SIRT1amelioratedsepticassociated-lunginjuryandmacrophagesapoptosisviainhibitingendoplasmicreticulumstress.CellSignal.2022Sep;97:110398.doi:10.1016/j.cellsig.2022.110398.Epub2022Jul8.PMID:35811055IF:4.850</p><p class="ql-block">10.YuJ,ZhangY,YuT,MiW,YaoS,WangZ,XuL,HuangY.PreoperativeAnxietyinChineseAdultPatientsUndergoingElectiveSurgeries:AMulticenterCross-SectionalStudy.WorldJSurg.2022Dec;46(12):2927-2938.doi:10.1007/s00268-022-06720-9.Epub2022Sep7.PMID:36070012;IF:3.28211.</p><p class="ql-block">11.XuJ,GaoC,HeY,FangX,SunD,PengZ,XiaoH,SunM,ZhangP,ZhouT,YangX,YuY,LiR,ZouX,ShuH,QiuY,ZhouX,YuanS,YaoS,ShangY.NLRC3expressioninmacrophageimpairsglycolysisandhostimmunedefensebymodulatingtheNF-κB-NFAT5complexduringsepticimmunosuppression.MolTher.2022Sep6:S1525-0016(22)00552-4.doi:10.1016/j.ymthe.2022.08.023.Epubaheadofprint.PMID:36068919;IF:12.91012.</p><p class="ql-block">12.WangF,WangC,XiaH,LinY,ZhangD,YinP,YaoS.BurdenofProstateCancerinChina,1990-2019:FindingsFromthe2019GlobalBurdenofDiseaseStudy.FrontEndocrinol(Lausanne).2022May25;13:853623.doi:10.3389/fendo.2022.853623.PMID:35692392;IF:6.05513.GeY,WangL,</p><p class="ql-block">13.WangC,ChenJ,DaiM,YaoS,LinY.CX3CL1inhibitsNLRP3inflammasome-inducedmicroglialpyroptosisandimprovesneuronalfunctioninmicewithexperimentally-inducedischemicstroke.LifeSci.2022Jul1;300:120564.doi:10.1016/j.lfs.2022.120564.Epub2022Apr22.PMID:35461837;IF:6.78014.</p><p class="ql-block">14.WangL,YaoC,ChenJ,GeY,WangC,WangY,WangF,SunY,DaiM,LinY,YaoS.γδTCellinCerebralIschemicStroke:Characteristic,Immunity-InflammatoryRole,andTherapy.FrontNeurol.2022Mar31;13:842212.doi:10.3389/fneur.2022.842212.PMID:35432162;IF:4.08615.</p><p class="ql-block">15.SunS,SunY,ChenR,YaoC,XiaH,ChenX,LinY,YaoS.DiaphragmultrasoundtoevaluatetheantagonisticeffectofsugammadexonrocuroniumafterliversurgeryinpatientswithdifferentliverChild-Pughgrades:studyprotocolforaprospective,double-blind,non-randomisedcontrolledtrial.BMJOpen.2022Feb1;12(2):e052279.doi:10.1136/bmjopen-2021-052279.PMID:35105573;IF:3.00616.</p><p class="ql-block">16.YaoW,WangT,JiangB,GaoF,WangL,ZhengH,XiaoW,YaoS,MeiW,ChenX,LuoA,SunL,CookT,BehringerE,HuitinkJM,WongDT,Lane-FallM,McNarryAF,McGuireB,HiggsA,ShahA,PatelA,ZuoM,MaW,XueZ,ZhangLM,LiW,WangY,HagbergC,O'SullivanEP,FleisherLA,WeiH;collaborators.Emergencytrachealintubationin202patientswithCOVID-19inWuhan,China:lessonslearntandinternationalexpertrecommendations.BrJAnaesth.2020Jul;125(1):e28-e37.doi:10.1016/j.bja.2020.03.026.Epub2020Apr10.PMID:32312571;IF:11.71917.</p><p class="ql-block">17.LiJ,LiM,LiL,MaJ,YaoC,YaoS.HydrogensulfideattenuatesferroptosisandstimulatesautophagybyblockingmTORsignalinginsepsis-inducedacutelunginjury.MolImmunol.2022Jan;141:318-327.doi:10.1016/j.molimm.2021.12.003.PMID:34952420;IF:4.174</p>